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Endocrine Abstracts

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ea0016p516 | Obesity | ECE2008

Chronic central infusion of a ghrelin receptor (GHS-R1A) antagonist to rats: impact on ICV ghrelin-induced food intake and altered body composition

Salome N , Gustafsson L , Taube M , Hansson C , Karlsson L , Fehrentz JA , Martinez J , Perrissoud D , Dickson SL

Central treatment with ghrelin increases body weight and fat accumulation. Here we explore the pharmacological effect of a combined central (ICV) infusion of ghrelin (0.3 nmol/day) and a recently developed ghrelin receptor (GHS-R1A) antagonist (JMV2959, 100 nmol/day) on food intake and body composition. The effect of ghrelin infusion for 14 days to increase body weight (20.7±0.9% vs 34.3±3.1%, saline vs ghrelin, P<0.001) was blocked by co-infusion with JMV...
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Endocrine Abstracts
ISSN 1470-3947 (print) | ISSN 1479-6848 (online)
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